Soybean is perhaps the best representative of an agronomic crop significantly affected by a plant-parasitic nematode in the United States. Soybean cyst nematode (Heterodera glycines) is the major pathogen of soybean causing over $1 billion in crop losses annually. SCN is now considered endemic to North America and is spreading as more acres of land are planted in soybean. In the past, chemical control of soybean cyst nematodes was proven to be effective. Most of the older and more cost-effective nematicides were derived from industrial by-products or broad-spectrum insecticidal chemistries. These nematicides were often very stable and lacked target specificity which led to contamination...