With the number of soybean acres increasing each year in southwest North Dakota, more information is needed on weed control methods for this important rotational crop. Weed control is vital for to successfully produce soybean in southwest North Dakota. In the no-till cropping system commonly used in southwest North Dakota, it is vitally important that weeds are controlled at planting to reduce competition for limited resources such as soil moisture and mineral nutrients. Many acres of soybean in southwest North Dakota will be with the glyphosate-resistant varieties developed through the NDSU Soybean Breeding Program. With glyphosate-resistant soybean, it will be very important to use preemergence herbicides at or before planting as postemergence options are limited and many weeds have already shown tolerance to glyphosate. This is especially true with weeds such as kochia, wild buckwheat, and common mallow, which are common in southwest North Dakota. Thus, it is vitally important that weeds be controlled prior to or at planting through application of herbicide combinations with postemergence and preemergence activity. Trials will be conducted to evaluate timing of preplant herbicides for weed control and herbicide tolerance.