The objectives of this work are to: 1) investigate new methodology for herbicide-resistance screening; 2) determine the frequency and distribution of waterhemp and other common and troublesome weeds in Ohio, collect waterhemp seed from fields with suspected herbicide-resistance, and conduct an herbicide screen to evaluate resistance; 3) initiate a long-term cover crop study evaluating the interactions between a rye cover crop and herbicide inputs on waterhemp density and seedbank dynamics; and 4) serve as a waterhemp management resource for growers, extension personnel, and crop consultants. Successful completion of this project will provide information on the management of waterhemp, allowing soybean growers to make informed decisions and maintain or increase profitability in the face of this growing threat.