There are many biological seed treatments marketed to growers under the premise that this practice will produce a positive ROI due to plant health promoting properties. At the 2022 Commodity Classic tradeshow listing, there are 20 companies with over 40 different biological seed treatment products marketed for soybean. Growers often purchase these products with the intention of maximizing yield to gain a competitive advantage. The effect of these products on yield, however, is largely undocumented. Here, we will evaluate commonly marketed biological seed treatment products across the U.S. This will help us identify environmental and soil factors where yield response to biological seed treatments is most likely to occur. The objectives of this research are to: 1) identify yield response in soybean to biological seed treatments (commonly marketed products), 2) conduct economic analysis on the value of these products, and 3) extend results to soybean growers through extension networks.