Updated June 12, 2024:
Executive Summary
The project, aimed at developing a machine-learning model to score distal intestinal histology slides for soybean meal-induced enteritis, was initial intended to officially commence on April 1, 2024; however, due to administrative delays, the contract was not signed until May 20, 2024 and a formal start date of May 1, 2024 was request. Despite these delays, significant progress was made in these initial months of the project, with a focus on algorithm development and initial model construction.
Q1 Project Activities and Achievements
1. Meetings and Planning:
Dr. Jacob Bledsoe (PI) and Dr. Nathan Redman (coPI) held multiple sessions to outline the construction of the ResNet algorithm and the sourcing of necessary histology slides. A pivotal 2-hour meeting involving the Project PI, Dr. Nathan Redman, and machine learning expert Anita Juhong occurred on May 25th. This meeting focused on determining the optimal parameters for constructing the ResNes analysis network, crucial for the project's success.
2. Development and Scripting of Neural Network:
The team, led by Dr. Nathan Redman, successfully developed and scripted version 1.1 of a ResNet-style architecture neural network utilizing the PyTorch framework. This version includes advanced features such as cross-entropy loss and a resource management CUDA module, ensuring efficient processing and management of computing resources.
3. Image Preprocessing Development:
Dr. Nathan Redman has begun initial scripting and development of the image preprocessing module, crucial for preparing raw histology slide data for neural network analysis. Utilizing Python Image Library and OpenCV, this module ensures that the raw image data are appropriately formatted to be optimized for input into the neural network.
4. Collaboration Changes:
Dr. Liam Neiswanger-Broughton of Washington State University had initially agreed to participate as a collaborating histopathologist, but has had to step away from the project. Discussions are currently underway with other potential histopathologists to assist with the manual ground-truth scoring of histological slides, a critical component for training our model.
Challenges and Adjustments
The delayed formal signing of the project contract posed initial administrative challenges; however, the team adapted quickly, ensuring that project milestones remained on track. The unexpected withdrawal of Dr. Broughton-Neiswanger necessitated a search for additional expertise, which is currently being addressed to minimize impact on the project timeline.
Next Steps
For the upcoming quarter, the focus will be on:
1. Finalizing collaborations with new histopathologists.
2. Beginning the collection and preprocessing of histology slides as per the project timeline.
3. Further refining and testing of the neural network model to ensure robustness and accuracy.
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