Soybean Phytophthora root rot disease control by computationally identifying virulence effectors in the causal agent, Phytophthora Sojae
Sustainable Production
Lead Principal Investigator:
Chi Zhang, University of Nebraska
Co-Principal Investigators:
Project Code:
Contributing Organization (Checkoff):
Institution Funded:
Brief Project Summary:

The general goal of this project is to uncover the mechanisms via which the virulence effectors
contribute to the development of soybean stem and root rot caused by P. Sojae. We have two
specific objectives: to identify virulence effectors and to study their functional mimicry to host
proteins that can reveal the mechanism of P. Sojaeā€™s pathogenicity.

Unique Keywords:
#breeding & genetics
Information And Results
Project Deliverables

This project will genome-wide identify virulence effectors in P. Sojae with the state-of-the-art
bioinformatics methods, and these virulence effectors are candidate targets of pathogen-resistant
methods. The PI was supported by Nebraska Soybean Board to study on the molecular mimicry
between bacterial pathogenic effectors and soybean proteins, and functions of bacterial effectors
were discovered by our designed protein structure modeling algorithms and modeled soybean
protein structures, which has been published. Though the oomycete and bacterial pathogens are
different, the principles of protein structure-function predictions are the same and the alreadymodeled
structures of soybean proteins will serve as a valuable resource for the proposed oomycete
pathogenic effector study. Therefore, we will explore the so-far blank research area of molecular
mimicry between oomycete effectors and soybean proteins by extending our protein structure
algorithms to P. Sojae. As a result, the mechanism under which P. Sojae interacts with and infects
soybean can be elucidated, which may directly lead to feasible and efficient methods to prevent

Final Project Results

Updated April 18, 2018:

View uploaded report PDF file

The United Soybean Research Retention policy will display final reports with the project once completed but working files will be purged after three years. And financial information after seven years. All pertinent information is in the final report or if you want more information, please contact the project lead at your state soybean organization or principal investigator listed on the project.