Globally, soybean is the largest source of both animal protein and vegetable oil that provides a variety of nutrients (N, P, K) and essential elements (Fe, Zn, etc.) that are very important for animal and human nutrition. A recent meta-analysis study has demonstrated that newer, high-yielding soybean cultivars, show decrease of 18 and 13% in seed P and K concentrations compared to older soybean cultivars, respectively (Balboa et al., 2018). In addition, wheat and soybean studies have observed that although newer cultivars always show higher yield, the micronutrient concentration (Fe, Zn) in the grains is significantly decreased (Garvin et al., 2006; Fritschi, personal communication). A decrease in mineral nutrient (N, P, K) and essential element concentrations (Fe, Zn, etc.) can reduce animal and human nutrition capacity of soybean (Myers et al., 2014). The causes underlying lower nutrient concentrations in high-yielding soybean cultivars are still unknown. It is hypothesized that the increased biomass accumulation and conversion to seed in the high yielding cultivars might dilute seed nutrients like P, K, Fe, and Zn. In addition, it is also hypothesized that the nutrient uptake and transport to the shoots may be mediated by the strength of the transpiration stream that pulls the nutrients from the soil to the leaves and seeds; therefore, cultivars that display lower transpiration may results in a lower nutrient content in the seed. Another possibility is that newer soybean cultivars need higher soil nutrient availability to maintain high seed nutrient content than is needed to maximize yield.