Aerial drone application technology has recently become available and may address limitations by providing greater agility to monitor and apply under conditions where obstacles and poor field conditions limit current pesticide application equipment. As aerial drones are more readily available, there is a great opportunity to develop research-based best practices and training for this new technology. In addition, changes in climate continue to affect the survival, distribution and aggressiveness of soybean pathogens. The goal of this research is to 1) determine the feasibility of fungicide application via drones as sustainable disease management tool; 2) continue to evaluate new and current fungicide products for efficacy and timing on management of foliar disease in soybean and protection of yield; and 3) to continue proactive monitoring to understand the distribution of soybean foliar diseases and fungicide resistance in Indiana that protect soybean yield and seed quality.